5LIT

Structure of the DNA duplex d(AAATTT)2 with the potential antiparasitic drug 6XV at 1.25 A resolution

5LIT の概要

• エントリーDOI: 10.2210/pdb5lit/pdb
• 分子名称: DNA (5'-D(*AP*AP*AP*TP*TP*T)-3'), 4-((4,5-dihydro-1H-imidazol-2-yl)amino)-N-(4-((4,5-dihydro-1H-imidazol-2-yl)amino)phenyl)benzamide dihydrochloride, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: all at dna, antiparasitic drug, minor groove binding drug, dna
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 8416.43

構造登録者

Millan, C.R.,Dardonville, C.,de Koning, H.P.,Saperas, N.,Lourdes Campos, J. (登録日: 2016-07-15, 公開日: 2017-06-14, 最終更新日: 2024-05-08)

• 主引用文献: Millan, C.R.,Acosta-Reyes, F.J.,Lagartera, L.,Ebiloma, G.U.,Lemgruber, L.,Nue Martinez, J.J.,Saperas, N.,Dardonville, C.,de Koning, H.P.,Campos, J.L.; Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast.; Nucleic Acids Res., 45:8378-8391, 2017; PubMed: 28637278; DOI: 10.1093/nar/gkx521

実験手法

X-RAY DIFFRACTION (1.25 Å)