5LI0

70S ribosome from Staphylococcus aureus

これはPDB形式変換不可エントリーです。

5LI0 の概要

• エントリーDOI: 10.2210/pdb5li0/pdb
• EMDBエントリー: 4050
• 分子名称: 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... (54 entities in total)
• 機能のキーワード: pathogenic ribosome, bl31 b-type, ribosome
• 由来する生物種: Staphylococcus aureus (strain NCTC 8325); 詳細
• タンパク質・核酸の鎖数: 50
• 化学式量合計: 2097739.57

構造登録者

Khusainov, I.,Vicens, Q.,Bochler, A.,Grosse, F.,Myasnikov, A.,Menetret, J.F.,Chicher, J.,Marzi, S.,Romby, P.,Yusupova, G.,Yusupov, M.,Hashem, Y. (登録日: 2016-07-13, 公開日: 2016-12-28, 最終更新日: 2024-05-15)

主引用文献

Khusainov, I.,Vicens, Q.,Bochler, A.,Grosse, F.,Myasnikov, A.,Menetret, J.F.,Chicher, J.,Marzi, S.,Romby, P.,Yusupova, G.,Yusupov, M.,Hashem, Y.
Structure of the 70S ribosome from human pathogen Staphylococcus aureus.
Nucleic Acids Res., 44:10491-10504, 2016

PubMed Abstract: Comparative structural studies of ribosomes from various organisms keep offering exciting insights on how species-specific or environment-related structural features of ribosomes may impact translation specificity and its regulation. Although the importance of such features may be less obvious within more closely related organisms, their existence could account for vital yet species-specific mechanisms of translation regulation that would involve stalling, cell survival and antibiotic resistance. Here, we present the first full 70S ribosome structure from Staphylococcus aureus, a Gram-positive pathogenic bacterium, solved by cryo-electron microscopy. Comparative analysis with other known bacterial ribosomes pinpoints several unique features specific to S. aureus around a conserved core, at both the protein and the RNA levels. Our work provides the structural basis for the many studies aiming at understanding translation regulation in S. aureus and for designing drugs against this often multi-resistant pathogen.

PubMed: 27906650
DOI: 10.1093/nar/gkw933

実験手法

ELECTRON MICROSCOPY (3.8 Å)