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5LHG

Structure of the KDM1A/CoREST complex with the inhibitor 4-methyl-N-[4-[[4-(1-methylpiperidin-4-yl)oxyphenoxy]methyl]phenyl]thieno[3,2-b]pyrrole-5-carboxamide

5LHG の概要
エントリーDOI10.2210/pdb5lhg/pdb
分子名称Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ... (6 entities in total)
機能のキーワードhistone demethylase, inhibitor, complex, oxidoreductase
由来する生物種Homo sapiens (Human)
詳細
タンパク質・核酸の鎖数2
化学式量合計148218.54
構造登録者
Cecatiello, V.,Pasqualato, S. (登録日: 2016-07-11, 公開日: 2017-02-22, 最終更新日: 2024-01-10)
主引用文献Vianello, P.,Sartori, L.,Amigoni, F.,Cappa, A.,Faga, G.,Fattori, R.,Legnaghi, E.,Ciossani, G.,Mattevi, A.,Meroni, G.,Moretti, L.,Cecatiello, V.,Pasqualato, S.,Romussi, A.,Thaler, F.,Trifiro, P.,Villa, M.,Botrugno, O.A.,Dessanti, P.,Minucci, S.,Vultaggio, S.,Zagarri, E.,Varasi, M.,Mercurio, C.
Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.
J. Med. Chem., 60:1693-1715, 2017
Cited by
PubMed: 28186757
DOI: 10.1021/acs.jmedchem.6b01019
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (3.34 Å)
構造検証レポート
Validation report summary of 5lhg
検証レポート(詳細版)ダウンロードをダウンロード

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件を2024-03-27に公開中

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