5LGU

Thieno[3,2-b]pyrrole-5-carboxamides as Novel Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1: Compound 34

5LGU の概要

• エントリーDOI: 10.2210/pdb5lgu/pdb
• 分子名称: Lysine-specific histone demethylase 1A, REST corepressor 1, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus : O60341 Q9UKL0
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 102771.39

構造登録者

Mattevi, A.,Ciossani, G. (登録日: 2016-07-08, 公開日: 2017-02-22, 最終更新日: 2024-01-10)

• 主引用文献: Vianello, P.,Sartori, L.,Amigoni, F.,Cappa, A.,Faga, G.,Fattori, R.,Legnaghi, E.,Ciossani, G.,Mattevi, A.,Meroni, G.,Moretti, L.,Cecatiello, V.,Pasqualato, S.,Romussi, A.,Thaler, F.,Trifiro, P.,Villa, M.,Botrugno, O.A.,Dessanti, P.,Minucci, S.,Vultaggio, S.,Zagarri, E.,Varasi, M.,Mercurio, C.; Thieno[3,2-b]pyrrole-5-carboxamides as New Reversible Inhibitors of Histone Lysine Demethylase KDM1A/LSD1. Part 2: Structure-Based Drug Design and Structure-Activity Relationship.; J. Med. Chem., 60:1693-1715, 2017; PubMed: 28186757; DOI: 10.1021/acs.jmedchem.6b01019

実験手法

X-RAY DIFFRACTION (3.2 Å)