5L72
PI3 kinase delta in complex with N-[6-(5-methanesulfonamido-6-methoxypyridin-3-yl)-1,3-dihydro-2-benzofuran-4-yl]-2-(morpholin-4-yl)acetamide
5L72 の概要
エントリーDOI | 10.2210/pdb5l72/pdb |
分子名称 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, N-[6-(5-methanesulfonamido-6-methoxypyridin-3-yl)-1,3-dihydro-2-benzofuran-4-yl]-2-(morpholin-4-yl)acetamide (3 entities in total) |
機能のキーワード | pi3 kinase delta, transferase |
由来する生物種 | Mus musculus (Mouse) |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 108284.17 |
構造登録者 | |
主引用文献 | Amour, A.,Barton, N.,Cooper, A.W.,Inglis, G.,Jamieson, C.,Luscombe, C.N.,Morrell, J.,Peace, S.,Perez, D.,Rowland, P.,Tame, C.,Uddin, S.,Vitulli, G.,Wellaway, N. Evolution of a Novel, Orally Bioavailable Series of PI3K delta Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease. J.Med.Chem., 59:7239-7251, 2016 Cited by PubMed: 27429068DOI: 10.1021/acs.jmedchem.6b00799 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.06 Å) |
構造検証レポート
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