5L71

Crystal structure of mouse phospholipid hydroperoxide glutathione peroxidase 4 (GPx4)

5L71 の概要

• エントリーDOI: 10.2210/pdb5l71/pdb
• 分子名称: Phospholipid hydroperoxide glutathione peroxidase, mitochondrial, 1,2-ETHANEDIOL (3 entities in total)
• 機能のキーワード: phospholipid hydroperoxide glutathione peroxidase 4 (gpx4), selenocysteine, oxidoreductase
• 由来する生物種: Mus musculus (Mouse)
• 細胞内の位置: Mitochondrion : O70325
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19745.79

構造登録者

Janowski, R.,Scanu, S.,Madl, T.,Niessing, D. (登録日: 2016-06-01, 公開日: 2016-10-19, 最終更新日: 2024-01-10)

主引用文献

Janowski, R.,Scanu, S.,Niessing, D.,Madl, T.
Crystal and solution structural studies of mouse phospholipid hydroperoxide glutathione peroxidase 4.
Acta Crystallogr.,Sect.F, 72:743-749, 2016

PubMed Abstract: The mammalian glutathione peroxidase (GPx) family is a key component of the cellular antioxidative defence system. Within this family, GPx4 has unique features as it accepts a large class of hydroperoxy lipid substrates and has a plethora of biological functions, including sperm maturation, regulation of apoptosis and cerebral embryogenesis. In this paper, the structure of the cytoplasmic isoform of mouse phospholipid hydroperoxide glutathione peroxidase (O70325-2 GPx4) with selenocysteine 46 mutated to cysteine is reported solved at 1.8 Å resolution using X-ray crystallography. Furthermore, solution data of an isotope-labelled GPx protein are presented.

PubMed: 27710939
DOI: 10.1107/S2053230X16013686

実験手法

X-RAY DIFFRACTION (1.8 Å)