5L6O
EphB3 kinase domain covalently bound to an irreversible inhibitor (compound 3)
Summary for 5L6O
| Entry DOI | 10.2210/pdb5l6o/pdb |
| Descriptor | Ephrin type-B receptor 3, 1-(4-phenylazanylquinazolin-7-yl)ethanone, 1,4-DIETHYLENE DIOXIDE, ... (4 entities in total) |
| Functional Keywords | kinase, irreversible inhibitor, quinazoline, signaling, transferase |
| Biological source | Homo sapiens (Human) |
| Cellular location | Cell membrane ; Single-pass type I membrane protein : P54753 |
| Total number of polymer chains | 1 |
| Total formula weight | 34117.11 |
| Authors | Schimpl, M.,Overman, R.,Kung, A.,Chen, Y.-C.,Ni, F.,Zhu, J.,Turner, M.,Molina, H.,Zhang, C. (deposition date: 2016-05-30, release date: 2016-08-10, Last modification date: 2024-01-10) |
| Primary citation | Kung, A.,Chen, Y.C.,Schimpl, M.,Ni, F.,Zhu, J.,Turner, M.,Molina, H.,Overman, R.,Zhang, C. Development of Specific, Irreversible Inhibitors for a Receptor Tyrosine Kinase EphB3. J.Am.Chem.Soc., 138:10554-10560, 2016 Cited by PubMed: 27478969DOI: 10.1021/jacs.6b05483 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.88 Å) |
Structure validation
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