5L4L
polyketide ketoreductase SimC7 - ternary complex with NADP+ and 7-oxo-SD8
Summary for 5L4L
Entry DOI | 10.2210/pdb5l4l/pdb |
Descriptor | SimC7, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total) |
Functional Keywords | short-chain dehydrogenase/reductase, ketoreductase, simocyclinone, dna gyrase inhibitor, oxidoreductase |
Biological source | Streptomyces antibioticus |
Total number of polymer chains | 1 |
Total formula weight | 34043.34 |
Authors | Schafer, M.,Stevenson, C.E.M.,Wilkinson, B.,Lawson, D.M.,Buttner, M.J. (deposition date: 2016-05-25, release date: 2016-10-05, Last modification date: 2024-01-10) |
Primary citation | Schafer, M.,Stevenson, C.E.,Wilkinson, B.,Lawson, D.M.,Buttner, M.J. Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate. Cell Chem Biol, 23:1091-1097, 2016 Cited by PubMed: 27617849DOI: 10.1016/j.chembiol.2016.07.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.2 Å) |
Structure validation
Download full validation report