5L4L

polyketide ketoreductase SimC7 - ternary complex with NADP+ and 7-oxo-SD8

Summary for 5L4L

Entry DOI	10.2210/pdb5l4l/pdb
Descriptor	SimC7, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	short-chain dehydrogenase/reductase, ketoreductase, simocyclinone, dna gyrase inhibitor, oxidoreductase
Biological source	Streptomyces antibioticus
Total number of polymer chains	1
Total formula weight	34043.34
Authors	Schafer, M.,Stevenson, C.E.M.,Wilkinson, B.,Lawson, D.M.,Buttner, M.J. (deposition date: 2016-05-25, release date: 2016-10-05, Last modification date: 2024-01-10)
Primary citation	Schafer, M.,Stevenson, C.E.,Wilkinson, B.,Lawson, D.M.,Buttner, M.J. Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate. Cell Chem Biol, 23:1091-1097, 2016 Cited by PubMed: 27617849 DOI: 10.1016/j.chembiol.2016.07.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.2 Å)

Structure validation