5L45
polyketide ketoreductase SimC7 - apo crystal form 2
Summary for 5L45
Entry DOI | 10.2210/pdb5l45/pdb |
Descriptor | SimC7, TETRAETHYLENE GLYCOL, GLYCEROL, ... (4 entities in total) |
Functional Keywords | short-chain dehydrogenase/reductase, ketoreductase, simocyclinone, dna gyrase inhibitor, hydrolase |
Biological source | Streptomyces antibioticus |
Total number of polymer chains | 2 |
Total formula weight | 64841.48 |
Authors | Schafer, M.,Stevenson, C.E.M.,Wilkinson, B.,Lawson, D.M.,Buttner, M.J. (deposition date: 2016-05-25, release date: 2016-10-05, Last modification date: 2024-01-10) |
Primary citation | Schafer, M.,Stevenson, C.E.,Wilkinson, B.,Lawson, D.M.,Buttner, M.J. Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate. Cell Chem Biol, 23:1091-1097, 2016 Cited by PubMed: 27617849DOI: 10.1016/j.chembiol.2016.07.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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