5L40

polyketide ketoreductase SimC7 - apo crystal form 1

Summary for 5L40

Entry DOI	10.2210/pdb5l40/pdb
Descriptor	polyketide ketoreductase SimC7 (2 entities in total)
Functional Keywords	short-chain dehydrogenase/reductase, ketoreductase, simocyclinone, dna gyrase inhibitor, oxidoreductase
Biological source	Streptomyces antibioticus
Total number of polymer chains	1
Total formula weight	32277.58
Authors	Schafer, M.,Stevenson, C.E.M.,Wilkinson, B.,Lawson, D.M.,Buttner, M.J. (deposition date: 2016-05-24, release date: 2016-10-05, Last modification date: 2024-01-10)
Primary citation	Schafer, M.,Stevenson, C.E.,Wilkinson, B.,Lawson, D.M.,Buttner, M.J. Substrate-Assisted Catalysis in Polyketide Reduction Proceeds via a Phenolate Intermediate. Cell Chem Biol, 23:1091-1097, 2016 Cited by PubMed: 27617849 DOI: 10.1016/j.chembiol.2016.07.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation