5L1M

CASKIN2 SAM domain tandem

Summary for 5L1M

Entry DOI	10.2210/pdb5l1m/pdb
Descriptor	Caskin-2 (1 entity in total)
Functional Keywords	signaling protein, protein interaction domain, sterile alpha motif, protein binding
Biological source	Homo sapiens (Human)
Cellular location	Cytoplasm : Q8WXE0
Total number of polymer chains	1
Total formula weight	20307.10
Authors	Donaldson, L.W.,Kwan, J.J.,Saridakis, V. (deposition date: 2016-07-29, release date: 2016-08-10, Last modification date: 2023-10-04)
Primary citation	Smirnova, E.,Kwan, J.J.,Siu, R.,Gao, X.,Zoidl, G.,Demeler, B.,Saridakis, V.,Donaldson, L.W. A new mode of SAM domain mediated oligomerization observed in the CASKIN2 neuronal scaffolding protein. Cell Commun. Signal, 14:17-17, 2016 Cited by PubMed Abstract: CASKIN2 is a homolog of CASKIN1, a scaffolding protein that participates in a signaling network with CASK (calcium/calmodulin-dependent serine kinase). Despite a high level of homology between CASKIN2 and CASKIN1, CASKIN2 cannot bind CASK due to the absence of a CASK Interaction Domain and consequently, may have evolved undiscovered structural and functional distinctions. PubMed: 27549312 DOI: 10.1186/s12964-016-0140-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.751 Å)

Structure validation