5L0K
Crystal Structure of Autotaxin and Compound PF-8380
Summary for 5L0K
Entry DOI | 10.2210/pdb5l0k/pdb |
Related | 5L0B 5L0E |
Descriptor | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total) |
Functional Keywords | phospholipase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Rattus norvegicus (Rat) |
Total number of polymer chains | 2 |
Total formula weight | 188869.98 |
Authors | Durbin, J.D. (deposition date: 2016-07-27, release date: 2016-08-10, Last modification date: 2020-07-29) |
Primary citation | Jones, S.B.,Pfeifer, L.A.,Bleisch, T.J.,Beauchamp, T.J.,Durbin, J.D.,Klimkowski, V.J.,Hughes, N.E.,Rito, C.J.,Dao, Y.,Gruber, J.M.,Bui, H.,Chambers, M.G.,Chandrasekhar, S.,Lin, C.,McCann, D.J.,Mudra, D.R.,Oskins, J.L.,Swearingen, C.A.,Thirunavukkarasu, K.,Norman, B.H. Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design. Acs Med.Chem.Lett., 7:857-861, 2016 Cited by PubMed: 27660691DOI: 10.1021/acsmedchemlett.6b00207 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.73 Å) |
Structure validation
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