5KX4

Structure of SALO

「4LU2」から置き換えられました

5KX4 の概要

• エントリーDOI: 10.2210/pdb5kx4/pdb
• 分子名称: 10.7 kDa salivary protein (2 entities in total)
• 機能のキーワード: insect protein, odorant-binding protein
• 由来する生物種: Lutzomyia longipalpis (Sand fly)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 23848.30

構造登録者

Asojo, O.A. (登録日: 2016-07-20, 公開日: 2016-07-27, 最終更新日: 2024-11-06)

主引用文献

Asojo, O.A.,Kelleher, A.,Liu, Z.,Pollet, J.,Hudspeth, E.M.,Rezende, W.C.,Groen, M.J.,Seid, C.A.,Abdeladhim, M.,Townsend, S.,de Castro, W.,Mendes-Sousa, A.,Bartholomeu, D.C.,Fujiwara, R.T.,Bottazzi, M.E.,Hotez, P.J.,Zhan, B.,Oliveira, F.,Kamhawi, S.,Valenzuela, J.G.
Structure of SALO, a leishmaniasis vaccine candidate from the sand fly Lutzomyia longipalpis.
PLoS Negl Trop Dis, 11:e0005374-e0005374, 2017

PubMed Abstract: Immunity to the sand fly salivary protein SALO (Salivary Anticomplement of Lutzomyia longipalpis) protected hamsters against Leishmania infantum and L. braziliensis infection and, more recently, a vaccine combination of a genetically modified Leishmania with SALO conferred strong protection against L. donovani infection. Because of the importance of SALO as a potential component of a leishmaniasis vaccine, a plan to produce this recombinant protein for future scale manufacturing as well as knowledge of its structural characteristics are needed to move SALO forward for the clinical path.

PubMed: 28278244
DOI: 10.1371/journal.pntd.0005374

実験手法

X-RAY DIFFRACTION (1.94 Å)