5KWW

Crystal Structure of Inhibitor JNJ-53718678 In Complex with Prefusion RSV F Glycoprotein

5KWW の概要

• エントリーDOI: 10.2210/pdb5kww/pdb
• 分子名称: Fusion glycoprotein F0, Envelope glycoprotein chimera, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, ... (6 entities in total)
• 機能のキーワード: class i viral fusion protein, respiratory syncytial virus, viral protein, fusion inhibitor, viral protein-inhibitor complex, viral protein/inhibitor
• 由来する生物種: Human respiratory syncytial virus; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 65108.39

構造登録者

McLellan, J.S.,Battles, M.B.,Arnoult, E.,Roymans, D.,Langedijk, J.P. (登録日: 2016-07-19, 公開日: 2017-08-02, 最終更新日: 2023-10-04)

• 主引用文献: Roymans, D.,Alnajjar, S.S.,Battles, M.B.,Sitthicharoenchai, P.,Furmanova-Hollenstein, P.,Rigaux, P.,Berg, J.V.D.,Kwanten, L.,Ginderen, M.V.,Verheyen, N.,Vranckx, L.,Jaensch, S.,Arnoult, E.,Voorzaat, R.,Gallup, J.M.,Larios-Mora, A.,Crabbe, M.,Huntjens, D.,Raboisson, P.,Langedijk, J.P.,Ackermann, M.R.,McLellan, J.S.,Vendeville, S.,Koul, A.; Therapeutic efficacy of a respiratory syncytial virus fusion inhibitor.; Nat Commun, 8:167-167, 2017; PubMed: 28761099; DOI: 10.1038/s41467-017-00170-x

実験手法

X-RAY DIFFRACTION (2.5 Å)