5KSX

Crystal structure of human FPPS in complex with an allosteric inhibitor AM-02-072

5KSX の概要

• エントリーDOI: 10.2210/pdb5ksx/pdb
• 分子名称: Farnesyl pyrophosphate synthase, PHOSPHATE ION, [[(2~{S})-2-[[6-(4-methylphenyl)thieno[2,3-d]pyrimidin-4-yl]amino]-3-phenyl-propanoyl]amino]phosphonic acid, ... (4 entities in total)
• 機能のキーワード: transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: P14324
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 44176.88

構造登録者

Park, J.,Matralis, A.,Tsantrizos, Y.S.,Berghuis, A.M. (登録日: 2016-07-10, 公開日: 2017-03-15, 最終更新日: 2023-10-04)

• 主引用文献: Park, J.,Leung, C.Y.,Matralis, A.N.,Lacbay, C.M.,Tsakos, M.,Fernandez De Troconiz, G.,Berghuis, A.M.,Tsantrizos, Y.S.; Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase.; J. Med. Chem., 60:2119-2134, 2017; PubMed: 28208018; DOI: 10.1021/acs.jmedchem.6b01888

実験手法

X-RAY DIFFRACTION (2.65 Å)