Summary for 5KQ5
| Descriptor | 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (9 entities in total) |
|---|---|
| Functional Keywords | kinase allosteric activator, transferase |
| Biological source | Rattus norvegicus (Rat) |
| Cellular location | Cytoplasm P54645 |
| Total number of polymer chains | 3 |
| Total molecular weight | 120426.34 |
| Authors | Calabrese, M.F.,Kurumbail, R.G. (deposition date: 2016-07-05, release date: 2016-08-17, Last modification date: 2017-11-01) |
| Primary citation | Cameron, K.O.,Kung, D.W.,Kalgutkar, A.S.,Kurumbail, R.G.,Miller, R.,Salatto, C.T.,Ward, J.,Withka, J.M.,Bhattacharya, S.K.,Boehm, M.,Borzilleri, K.A.,Brown, J.A.,Calabrese, M.,Caspers, N.L.,Cokorinos, E.,Conn, E.L.,Dowling, M.S.,Edmonds, D.J.,Eng, H.,Fernando, D.P.,Frisbie, R.,Hepworth, D.,Landro, J.,Mao, Y.,Rajamohan, F.,Reyes, A.R.,Rose, C.R.,Ryder, T.,Shavnya, A.,Smith, A.C.,Tu, M.,Wolford, A.C.,Xiao, J. Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy. J.Med.Chem., 59:8068-8081, 2016 PubMed: 27490827 (PDB entries with the same primary citation) DOI: 10.1021/acs.jmedchem.6b00866  Import into Mendeley |
| Experimental method | X-RAY DIFFRACTION (3.41 Å) |
