5KE0
Discovery of 1-1H-Pyrazolo 4,3-c pyridine-6-yl urea Inhibitors of Extracellular Signal Regulated Kinase ERK for the Treatment of Cancers
Summary for 5KE0
Entry DOI | 10.2210/pdb5ke0/pdb |
Descriptor | Mitogen-activated protein kinase 1, 1-[3-(2-methylpyridin-4-yl)-1~{H}-pyrazolo[4,3-c]pyridin-6-yl]-3-(phenylmethyl)urea, SULFATE ION, ... (4 entities in total) |
Functional Keywords | transferase, serine/threonine-protein kinase, map kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Rattus norvegicus (Rat) |
Cellular location | Cytoplasm, cytoskeleton, spindle : P63086 |
Total number of polymer chains | 1 |
Total formula weight | 43200.42 |
Authors | |
Primary citation | Lim, J.,Kelley, E.H.,Methot, J.L.,Zhou, H.,Petrocchi, A.,Chen, H.,Hill, S.E.,Hinton, M.C.,Hruza, A.,Jung, J.O.,Maclean, J.K.,Mansueto, M.,Naumov, G.N.,Philippar, U.,Raut, S.,Spacciapoli, P.,Sun, D.,Siliphaivanh, P. Discovery of 1-(1H-Pyrazolo[4,3-c]pyridin-6-yl)urea Inhibitors of Extracellular Signal-Regulated Kinase (ERK) for the Treatment of Cancers. J.Med.Chem., 59:6501-6511, 2016 Cited by PubMed: 27329786DOI: 10.1021/acs.jmedchem.6b00708 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.68 Å) |
Structure validation
Download full validation report