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5KCC

Crystal Structure of the ER-alpha Ligand-binding Domain (Y537S) in Complex with Oxabicyclic Heptene Sulfonamide (OBHS-N)

Replaces:  4ZUB
Summary for 5KCC
Entry DOI10.2210/pdb5kcc/pdb
Related5KCD 5KCF 5KCT 5KCU 5KCW 5KD9
DescriptorEstrogen receptor, NCOA2, (1S,2R,4S)-5,6-bis(4-hydroxyphenyl)-N-phenyl-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonamide, ... (4 entities in total)
Functional Keywordsnuclear receptor, transcription factor, ligand binding, protein-ligand complex, transcription
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains4
Total formula weight62803.94
Authors
Primary citationSrinivasan, S.,Nwachukwu, J.C.,Bruno, N.E.,Dharmarajan, V.,Goswami, D.,Kastrati, I.,Novick, S.,Nowak, J.,Cavett, V.,Zhou, H.B.,Boonmuen, N.,Zhao, Y.,Min, J.,Frasor, J.,Katzenellenbogen, B.S.,Griffin, P.R.,Katzenellenbogen, J.A.,Nettles, K.W.
Full antagonism of the estrogen receptor without a prototypical ligand side chain.
Nat. Chem. Biol., 13:111-118, 2017
Cited by
PubMed: 27870835
DOI: 10.1038/nchembio.2236
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.386 Å)
Structure validation

217705

數據於2024-03-27公開中

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