5KBQ
Pak1 in complex with bis-anilino pyrimidine inhibitor
Summary for 5KBQ
Entry DOI | 10.2210/pdb5kbq/pdb |
Descriptor | Serine/threonine-protein kinase PAK 1, [4-methyl-3-[methyl-[2-[(3-methylsulfonyl-5-morpholin-4-yl-phenyl)amino]pyrimidin-4-yl]amino]phenyl]methanol (3 entities in total) |
Functional Keywords | serine/threonine-protein kinase pak1, kinase, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q13153 |
Total number of polymer chains | 2 |
Total formula weight | 65148.28 |
Authors | Ferguson, A. (deposition date: 2016-06-03, release date: 2016-09-28, Last modification date: 2023-09-27) |
Primary citation | McCoull, W.,Hennessy, E.J.,Blades, K.,Chuaqui, C.,Dowling, J.E.,Ferguson, A.D.,Goldberg, F.W.,Howe, N.,Jones, C.R.,Kemmitt, P.D.,Lamont, G.,Varnes, J.G.,Ward, R.A.,Yang, B. Optimization of Highly Kinase Selective Bis-anilino Pyrimidine PAK1 Inhibitors. ACS Med Chem Lett, 7:1118-1123, 2016 Cited by PubMed: 27994749DOI: 10.1021/acsmedchemlett.6b00322 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.58 Å) |
Structure validation
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