5KAN

Crystal structure of multidonor HV1-18-class broadly neutralizing Influenza A antibody 16.g.07 in complex with A/Hong Kong/1-4-MA21-1/1968 (H3N2) Hemagglutinin

5KAN の概要

• エントリーDOI: 10.2210/pdb5kan/pdb
• 関連するPDBエントリー: 5KAQ
• 分子名称: Hemagglutinin HA1, Hemagglutinin HA2, 16.g.07 Heavy chain, ... (6 entities in total)
• 機能のキーワード: influenza, multidonor, h5, universal influenza vaccine, immune system
• 由来する生物種: Influenza A virus (strain A/Hong Kong/1/1968 H3N2); 詳細
• 細胞内の位置: Virion membrane ; Single-pass type I membrane protein : Q91MA7 Q91MA7
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 314040.85

構造登録者

Joyce, M.G.,Thomas, P.V.,Wheatley, A.K.,McDermott, A.B.,Mascola, J.R.,Kwong, P.D. (登録日: 2016-06-01, 公開日: 2016-11-30, 最終更新日: 2023-09-27)

• 主引用文献: Joyce, M.G.,Wheatley, A.K.,Thomas, P.V.,Chuang, G.Y.,Soto, C.,Bailer, R.T.,Druz, A.,Georgiev, I.S.,Gillespie, R.A.,Kanekiyo, M.,Kong, W.P.,Leung, K.,Narpala, S.N.,Prabhakaran, M.S.,Yang, E.S.,Zhang, B.,Zhang, Y.,Asokan, M.,Boyington, J.C.,Bylund, T.,Darko, S.,Lees, C.R.,Ransier, A.,Shen, C.H.,Wang, L.,Whittle, J.R.,Wu, X.,Yassine, H.M.,Santos, C.,Matsuoka, Y.,Tsybovsky, Y.,Baxa, U.,Mullikin, J.C.,Subbarao, K.,Douek, D.C.,Graham, B.S.,Koup, R.A.,Ledgerwood, J.E.,Roederer, M.,Shapiro, L.,Kwong, P.D.,Mascola, J.R.,McDermott, A.B.; Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses.; Cell(Cambridge,Mass.), 166:609-623, 2016; PubMed: 27453470; DOI: 10.1016/j.cell.2016.06.043

実験手法

X-RAY DIFFRACTION (2.785 Å)