5KAE
Crystal structure of human PI3K-gamma in complex with quinoline-containing inhibitor 5g
5KAE の概要
エントリーDOI | 10.2210/pdb5kae/pdb |
分子名称 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 4-azanyl-6-[[(1~{S})-1-(6-fluoranyl-3-phenyl-4-piperazin-1-ylcarbonyl-quinolin-2-yl)ethyl]amino]pyrimidine-5-carbonitrile, ... (4 entities in total) |
機能のキーワード | phosphotransferase, inhibitor, inflammatory disease, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Cytoplasm : P48736 |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 110551.73 |
構造登録者 | |
主引用文献 | Gonzalez-Lopez de Turiso, F.,Hao, X.,Shin, Y.,Bui, M.,Campuzano, I.,Cardozo, M.,Dunn, M.C.,Duquette, J.,Fisher, B.,Foti, R.S.,Henne, K.,He, X.,Hu, Y.-L.,Kelly, R.C.,Johnson, M.G.,Lucas, B.S.,McCarter, J.,McGee, L.R.,Medina, J.C.,Metz, D.,San Miguel, T.,Mohn, D.,Tran, T.,Vissinga, C.,Wannberg, S.,Whittington, D.A.,Whoriskey, J.,Yu, G.,Zalameda, L.,Zhang, X.,Cushing, T.D. Discovery and in vivo evaluation of the potent and selective PI3K-delta inhibitors AM-0687 and AM-1430 To Be Published, |
実験手法 | X-RAY DIFFRACTION (2.65 Å) |
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