5K6A

Trypanosoma brucei Pteridine reductase 1 (PTR1) in complex with compound 1

Summary for 5K6A

Entry DOI	10.2210/pdb5k6a/pdb
Descriptor	Pteridine reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2~{R})-2-(3-hydroxyphenyl)-6-oxidanyl-2,3-dihydrochromen-4-one, ... (6 entities in total)
Functional Keywords	trypanosoma brucei, pteridine reductase, oxidoreductase
Biological source	Trypanosoma brucei brucei More
Total number of polymer chains	4
Total formula weight	126907.87
Authors	Landi, G.,Pozzi, C.,Di Pisa, F.,Dello lacono, L.,Mangani, S. (deposition date: 2016-05-24, release date: 2017-03-22, Last modification date: 2024-01-10)
Primary citation	Di Pisa, F.,Landi, G.,Dello Iacono, L.,Pozzi, C.,Borsari, C.,Ferrari, S.,Santucci, M.,Santarem, N.,Cordeiro-da-Silva, A.,Moraes, C.B.,Alcantara, L.M.,Fontana, V.,Freitas-Junior, L.H.,Gul, S.,Kuzikov, M.,Behrens, B.,Pohner, I.,Wade, R.C.,Costi, M.P.,Mangani, S. Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity. Molecules, 22:-, 2017 Cited by PubMed: 28282886 DOI: 10.3390/molecules22030426 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation