5K5N
Crystal structure of GSK-3beta complexed with PF-04802367, a highly selective brain-penetrant kinase inhibitor
5K5N の概要
エントリーDOI | 10.2210/pdb5k5n/pdb |
分子名称 | Glycogen synthase kinase-3 beta, 5-(3-chloranyl-4-methoxy-phenyl)-~{N}-[3-(1,2,4-triazol-1-yl)propyl]-1,3-oxazole-4-carboxamide, SULFATE ION, ... (4 entities in total) |
機能のキーワード | protein kinase, alzhimer's disease, tau kinase, transferase |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Cytoplasm: P49841 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 85170.04 |
構造登録者 | |
主引用文献 | Liang, S.H.,Chen, J.M.,Normandin, M.D.,Chang, J.S.,Chang, G.C.,Taylor, C.K.,Trapa, P.,Plummer, M.S.,Para, K.S.,Conn, E.L.,Lopresti-Morrow, L.,Lanyon, L.F.,Cook, J.M.,Richter, K.E.,Nolan, C.E.,Schachter, J.B.,Janat, F.,Che, Y.,Shanmugasundaram, V.,Lefker, B.A.,Enerson, B.E.,Livni, E.,Wang, L.,Guehl, N.J.,Patnaik, D.,Wagner, F.F.,Perlis, R.,Holson, E.B.,Haggarty, S.J.,El Fakhri, G.,Kurumbail, R.G.,Vasdev, N. Discovery of a Highly Selective Glycogen Synthase Kinase-3 Inhibitor (PF-04802367) That Modulates Tau Phosphorylation in the Brain: Translation for PET Neuroimaging. Angew.Chem.Int.Ed.Engl., 55:9601-9605, 2016 Cited by PubMed: 27355874DOI: 10.1002/anie.201603797 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.2 Å) |
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