5K59

Crystal structure of LukGH from Staphylococcus aureus in complex with a neutralising antibody

Summary for 5K59

• Entry DOI: 10.2210/pdb5k59/pdb
• Related: 4TW1
• Descriptor: Uncharacterized leukocidin-like protein 2, Uncharacterized leukocidin-like protein 1, Fab heavy chain, ... (8 entities in total)
• Functional Keywords: toxin neutralizing monoclonal antibody, conformational epitope, x-ray crystal structure, immune system
• Biological source: Staphylococcus aureus (strain USA300); More
• Total number of polymer chains: 8
• Total formula weight: 241271.82

Authors

Welin, M.,Logan, D.T.,Badarau, A.,Mirkina, I.,Zauner, G.,Dolezilkova, I.,Nagy, E. (deposition date: 2016-05-23, release date: 2016-08-10, Last modification date: 2018-01-17)

• Primary citation: Badarau, A.,Rouha, H.,Malafa, S.,Battles, M.B.,Walker, L.,Nielson, N.,Dolezilkova, I.,Teubenbacher, A.,Banerjee, S.,Maierhofer, B.,Weber, S.,Stulik, L.,Logan, D.T.,Welin, M.,Mirkina, I.,Pleban, C.,Zauner, G.,Gross, K.,Jagerhofer, M.,Magyarics, Z.,Nagy, E.; Context matters: The importance of dimerization-induced conformation of the LukGH leukocidin of Staphylococcus aureus for the generation of neutralizing antibodies.; Mabs, 8:1347-1360, 2016; PubMed: 27467113; DOI: 10.1080/19420862.2016.1215791

Experimental method

X-RAY DIFFRACTION (2.84 Å)