5K59

Crystal structure of LukGH from Staphylococcus aureus in complex with a neutralising antibody

5K59 の概要

• エントリーDOI: 10.2210/pdb5k59/pdb
• 関連するPDBエントリー: 4TW1
• 分子名称: Uncharacterized leukocidin-like protein 2, Uncharacterized leukocidin-like protein 1, Fab heavy chain, ... (8 entities in total)
• 機能のキーワード: toxin neutralizing monoclonal antibody, conformational epitope, x-ray crystal structure, immune system
• 由来する生物種: Staphylococcus aureus (strain USA300); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 241271.82

構造登録者

Welin, M.,Logan, D.T.,Badarau, A.,Mirkina, I.,Zauner, G.,Dolezilkova, I.,Nagy, E. (登録日: 2016-05-23, 公開日: 2016-08-10, 最終更新日: 2018-01-17)

• 主引用文献: Badarau, A.,Rouha, H.,Malafa, S.,Battles, M.B.,Walker, L.,Nielson, N.,Dolezilkova, I.,Teubenbacher, A.,Banerjee, S.,Maierhofer, B.,Weber, S.,Stulik, L.,Logan, D.T.,Welin, M.,Mirkina, I.,Pleban, C.,Zauner, G.,Gross, K.,Jagerhofer, M.,Magyarics, Z.,Nagy, E.; Context matters: The importance of dimerization-induced conformation of the LukGH leukocidin of Staphylococcus aureus for the generation of neutralizing antibodies.; Mabs, 8:1347-1360, 2016; PubMed: 27467113; DOI: 10.1080/19420862.2016.1215791

実験手法

X-RAY DIFFRACTION (2.84 Å)