5K4Z

M. thermoresistible IMPDH in complex with IMP and Compound 6

5K4Z の概要

• エントリーDOI: 10.2210/pdb5k4z/pdb
• 分子名称: Inosine-5'-monophosphate dehydrogenase,Inosine-5'-monophosphate dehydrogenase, INOSINIC ACID, ~{N}-(4-fluorophenyl)-4-(2~{H}-indazol-6-ylsulfamoyl)-3,5-dimethyl-1~{H}-pyrrole-2-carboxamide, ... (4 entities in total)
• 機能のキーワード: impdh, guab2, inhibitor-complex, oxidoreductase
• 由来する生物種: Mycobacterium thermoresistibile; 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 40630.13

構造登録者

Pacitto, A.,Ascher, D.B.,Blundell, T.L. (登録日: 2016-05-22, 公開日: 2016-10-19, 最終更新日: 2017-01-25)

• 主引用文献: Park, Y.,Pacitto, A.,Bayliss, T.,Cleghorn, L.A.,Wang, Z.,Hartman, T.,Arora, K.,Ioerger, T.R.,Sacchettini, J.,Rizzi, M.,Donini, S.,Blundell, T.L.,Ascher, D.B.,Rhee, K.,Breda, A.,Zhou, N.,Dartois, V.,Jonnala, S.R.,Via, L.E.,Mizrahi, V.,Epemolu, O.,Stojanovski, L.,Simeons, F.,Osuna-Cabello, M.,Ellis, L.,MacKenzie, C.J.,Smith, A.R.,Davis, S.H.,Murugesan, D.,Buchanan, K.I.,Turner, P.A.,Huggett, M.,Zuccotto, F.,Rebollo-Lopez, M.J.,Lafuente-Monasterio, M.J.,Sanz, O.,Diaz, G.S.,Lelievre, J.,Ballell, L.,Selenski, C.,Axtman, M.,Ghidelli-Disse, S.,Pflaumer, H.,Bosche, M.,Drewes, G.,Freiberg, G.M.,Kurnick, M.D.,Srikumaran, M.,Kempf, D.J.,Green, S.R.,Ray, P.C.,Read, K.,Wyatt, P.,Barry, C.E.,Boshoff, H.I.; Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis.; ACS Infect Dis, 3:18-33, 2017; PubMed: 27704782; DOI: 10.1021/acsinfecdis.6b00103

実験手法

X-RAY DIFFRACTION (1.64 Å)