5K4P

Catalytic Domain of MCR-1 phosphoethanolamine transferase

5K4P の概要

• エントリーDOI: 10.2210/pdb5k4p/pdb
• 分子名称: Probable phosphatidylethanolamine transferase Mcr-1, ZINC ION, sorbitol, ... (4 entities in total)
• 機能のキーワード: phosphoethanolamine transferase, alpha/beta/alpha fold, alkaline phosphatase superfamily, transferase
• 由来する生物種: Escherichia coli BL21(DE3)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39345.18

構造登録者

Stojanoski, V.,Palzkill, T.,Prasad, B.V.V.,Sankaran, B. (登録日: 2016-05-21, 公開日: 2016-08-31, 最終更新日: 2024-10-09)

主引用文献

Stojanoski, V.,Sankaran, B.,Prasad, B.V.,Poirel, L.,Nordmann, P.,Palzkill, T.
Structure of the catalytic domain of the colistin resistance enzyme MCR-1.
Bmc Biol., 14:81-81, 2016

PubMed Abstract: Due to the paucity of novel antibiotics, colistin has become a last resort antibiotic for treating multidrug resistant bacteria. Colistin acts by binding the lipid A component of lipopolysaccharides and subsequently disrupting the bacterial membrane. The recently identified plasmid-encoded MCR-1 enzyme is the first transmissible colistin resistance determinant and is a cause for concern for the spread of this resistance trait. MCR-1 is a phosphoethanolamine transferase that catalyzes the addition of phosphoethanolamine to lipid A to decrease colistin affinity.

PubMed: 27655155
DOI: 10.1186/s12915-016-0303-0

実験手法

X-RAY DIFFRACTION (1.318 Å)