5K48
VIM-2 Metallo Beta Lactamase in complex with 3-(mercaptomethyl)-[1,1'-biphenyl]-4-carboxylic acid
Summary for 5K48
| Entry DOI | 10.2210/pdb5k48/pdb |
| Descriptor | Beta-lactamase VIM-2, 4-phenyl-2-(sulfanylmethyl)benzoic acid, FORMIC ACID, ... (5 entities in total) |
| Functional Keywords | metallo beta-lactamase, antibiotic resistance, carbapenamase. inhibitor, hydrolase |
| Biological source | Pseudomonas aeruginosa |
| Total number of polymer chains | 2 |
| Total formula weight | 52498.17 |
| Authors | Zollman, D.,McDonough, M.,Brem, J.,Schofield, C. (deposition date: 2016-05-20, release date: 2017-06-07, Last modification date: 2024-01-10) |
| Primary citation | Cain, R.,Brem, J.,Zollman, D.,McDonough, M.A.,Johnson, R.M.,Spencer, J.,Makena, A.,Abboud, M.I.,Cahill, S.,Lee, S.Y.,McHugh, P.J.,Schofield, C.J.,Fishwick, C.W.G. In Silico Fragment-Based Design Identifies Subfamily B1 Metallo-beta-lactamase Inhibitors. J. Med. Chem., 61:1255-1260, 2018 Cited by PubMed: 29271657DOI: 10.1021/acs.jmedchem.7b01728 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.744 Å) |
Structure validation
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