5K33
Crystal structure of extracellular domain of HER2 in complex with Fcab STAB19
5K33 の概要
エントリーDOI | 10.2210/pdb5k33/pdb |
分子名称 | Ig gamma-1 chain C region, Receptor tyrosine-protein kinase erbB-2, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total) |
機能のキーワード | immune system, antibody engineering, immunoglobulin g1, fc fragment, glycosylations, ch3 domain, fcab, human epidermal growth factor receptor 2, her2/neu, erbb-2, cell surface receptor |
由来する生物種 | Homo sapiens (Human) 詳細 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 94751.04 |
構造登録者 | Humm, A.,Lobner, E.,Goritzer, K.,Mlynek, G.,Obinger, C.,Djinovic-Carugo, K. (登録日: 2016-05-19, 公開日: 2017-04-12, 最終更新日: 2024-01-10) |
主引用文献 | Lobner, E.,Humm, A.S.,Goritzer, K.,Mlynek, G.,Puchinger, M.G.,Hasenhindl, C.,Ruker, F.,Traxlmayr, M.W.,Djinovic-Carugo, K.,Obinger, C. Fcab-HER2 Interaction: a Menage a Trois. Lessons from X-Ray and Solution Studies. Structure, 25:878-889.e5, 2017 Cited by PubMed: 28528777DOI: 10.1016/j.str.2017.04.014 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (3.3 Å) |
構造検証レポート
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