5K00

MELK in complex with NVS-MELK5

5K00 の概要

• エントリーDOI: 10.2210/pdb5k00/pdb
• 分子名称: Maternal embryonic leucine zipper kinase, 4-{2-[(3-methoxyphenyl)amino]-4-[(piperidin-4-yl)methoxy]pyrimidin-5-yl}-N-[2-oxo-2-(phenylamino)ethyl]benzamide (3 entities in total)
• 機能のキーワード: kinase uba typeii inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cell membrane ; Peripheral membrane protein : Q14680
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39525.73

構造登録者

Sprague, E.R. (登録日: 2016-05-17, 公開日: 2017-03-01, 最終更新日: 2024-03-06)

• 主引用文献: Chen, X.,Giraldes, J.,Sprague, E.R.,Shakya, S.,Chen, Z.,Wang, Y.,Joud, C.,Mathieu, S.,Chen, C.H.,Straub, C.,Duca, J.,Hurov, K.,Yuan, Y.,Shao, W.,Toure, B.B.; "Addition" and "Subtraction": Selectivity Design for Type II Maternal Embryonic Leucine Zipper Kinase Inhibitors.; J. Med. Chem., 60:2155-2161, 2017; PubMed: 28186750; DOI: 10.1021/acs.jmedchem.7b00033

実験手法

X-RAY DIFFRACTION (1.77 Å)