5JZS

HsaD bound to 3,5-dichloro-4-hydroxybenzoic acid

Summary for 5JZS

Entry DOI	10.2210/pdb5jzs/pdb
Related	2VF2 5JZ9 5JZB
Descriptor	2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD, 3,5-dichloro-4-hydroxybenzoic acid (3 entities in total)
Functional Keywords	hsad, inhibitor, m. tuberculosis, cholesterol, infection, hydrolase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	2
Total formula weight	62397.99
Authors	Ryan, A.,Polycarpou, E.,Lack, N.,Evangelopoulos, D.,Sieg, C.,Halman, A.,Bhakta, S.,Sinclair, A.,Eleftheriadou, O.,McHugh, T.D.,Keany, S.,Lowe, E.D.,Ballet, R.,Abuhammad, A.,Ciulli, A.,Sim, E. (deposition date: 2016-05-17, release date: 2017-04-05, Last modification date: 2024-01-10)
Primary citation	Ryan, A.,Polycarpou, E.,Lack, N.A.,Evangelopoulos, D.,Sieg, C.,Halman, A.,Bhakta, S.,Eleftheriadou, O.,McHugh, T.D.,Keany, S.,Lowe, E.D.,Ballet, R.,Abuhammad, A.,Jacobs, W.R.,Ciulli, A.,Sim, E. Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach. Br. J. Pharmacol., 174:2209-2224, 2017 Cited by PubMed: 28380256 DOI: 10.1111/bph.13810 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.27 Å)

Structure validation