5JZS

HsaD bound to 3,5-dichloro-4-hydroxybenzoic acid

5JZS の概要

• エントリーDOI: 10.2210/pdb5jzs/pdb
• 関連するPDBエントリー: 2VF2 5JZ9 5JZB
• 分子名称: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD, 3,5-dichloro-4-hydroxybenzoic acid (3 entities in total)
• 機能のキーワード: hsad, inhibitor, m. tuberculosis, cholesterol, infection, hydrolase
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62397.99

構造登録者

Ryan, A.,Polycarpou, E.,Lack, N.,Evangelopoulos, D.,Sieg, C.,Halman, A.,Bhakta, S.,Sinclair, A.,Eleftheriadou, O.,McHugh, T.D.,Keany, S.,Lowe, E.D.,Ballet, R.,Abuhammad, A.,Ciulli, A.,Sim, E. (登録日: 2016-05-17, 公開日: 2017-04-05, 最終更新日: 2024-01-10)

• 主引用文献: Ryan, A.,Polycarpou, E.,Lack, N.A.,Evangelopoulos, D.,Sieg, C.,Halman, A.,Bhakta, S.,Eleftheriadou, O.,McHugh, T.D.,Keany, S.,Lowe, E.D.,Ballet, R.,Abuhammad, A.,Jacobs, W.R.,Ciulli, A.,Sim, E.; Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.; Br. J. Pharmacol., 174:2209-2224, 2017; PubMed: 28380256; DOI: 10.1111/bph.13810

実験手法

X-RAY DIFFRACTION (2.27 Å)