5JZ9

Crystal structure of HsaD bound to 3,5-dichloro-4-hydroxybenzenesulphonic acid

5JZ9 の概要

• エントリーDOI: 10.2210/pdb5jz9/pdb
• 関連するPDBエントリー: 2VF2
• 分子名称: 4,5:9,10-diseco-3-hydroxy-5,9,17-trioxoandrosta-1(10),2-diene-4-oate hydrolase, 3,5-dichloro-4-hydroxybenzene-1-sulfonic acid (3 entities in total)
• 機能のキーワード: hsad, m. tuberculosis, cholesterol, inhibitor, mcp-hydrolase, hydrolase
• 由来する生物種: Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62677.11

構造登録者

Ryan, A.,Polycarpou, E.,Lack, N.A.,Evangelopoulos, D.,Sieg, C.,Halman, A.,Bhakta, S.,Sinclair, A.,Eleftheriadou, O.,McHugh, T.D.,Keany, S.,Lowe, E.,Ballet, R.,Abihammad, A.,Ciulli, A.,Sim, E. (登録日: 2016-05-16, 公開日: 2017-04-05, 最終更新日: 2024-01-10)

• 主引用文献: Ryan, A.,Polycarpou, E.,Lack, N.A.,Evangelopoulos, D.,Sieg, C.,Halman, A.,Bhakta, S.,Eleftheriadou, O.,McHugh, T.D.,Keany, S.,Lowe, E.D.,Ballet, R.,Abuhammad, A.,Jacobs, W.R.,Ciulli, A.,Sim, E.; Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach.; Br. J. Pharmacol., 174:2209-2224, 2017; PubMed: 28380256; DOI: 10.1111/bph.13810

実験手法

X-RAY DIFFRACTION (2.68 Å)