5JZ7
NGF IN COMPLEX WITH MEDI578 scFv
Summary for 5JZ7
Entry DOI | 10.2210/pdb5jz7/pdb |
Descriptor | Beta-nerve growth factor, MEDI578 scFv, heavy chain, MEDI578 scFv, light chain (3 entities in total) |
Functional Keywords | antibody, complex, epitope, ngf, signaling protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Secreted: P01138 |
Total number of polymer chains | 12 |
Total formula weight | 156350.41 |
Authors | Olsson, L.-L.,Aagaard, A. (deposition date: 2016-05-16, release date: 2017-01-11, Last modification date: 2024-01-10) |
Primary citation | Dobson, C.L.,Devine, P.W.,Phillips, J.J.,Higazi, D.R.,Lloyd, C.,Popovic, B.,Arnold, J.,Buchanan, A.,Lewis, A.,Goodman, J.,van der Walle, C.F.,Thornton, P.,Vinall, L.,Lowne, D.,Aagaard, A.,Olsson, L.L.,Ridderstad Wollberg, A.,Welsh, F.,Karamanos, T.K.,Pashley, C.L.,Iadanza, M.G.,Ranson, N.A.,Ashcroft, A.E.,Kippen, A.D.,Vaughan, T.J.,Radford, S.E.,Lowe, D.C. Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo. Sci Rep, 6:38644-38644, 2016 Cited by PubMed: 27995962DOI: 10.1038/srep38644 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
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