5JZ7

NGF IN COMPLEX WITH MEDI578 scFv

5JZ7 の概要

• エントリーDOI: 10.2210/pdb5jz7/pdb
• 分子名称: Beta-nerve growth factor, MEDI578 scFv, heavy chain, MEDI578 scFv, light chain (3 entities in total)
• 機能のキーワード: antibody, complex, epitope, ngf, signaling protein
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Secreted: P01138
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 156350.41

構造登録者

Olsson, L.-L.,Aagaard, A. (登録日: 2016-05-16, 公開日: 2017-01-11, 最終更新日: 2024-01-10)

• 主引用文献: Dobson, C.L.,Devine, P.W.,Phillips, J.J.,Higazi, D.R.,Lloyd, C.,Popovic, B.,Arnold, J.,Buchanan, A.,Lewis, A.,Goodman, J.,van der Walle, C.F.,Thornton, P.,Vinall, L.,Lowne, D.,Aagaard, A.,Olsson, L.L.,Ridderstad Wollberg, A.,Welsh, F.,Karamanos, T.K.,Pashley, C.L.,Iadanza, M.G.,Ranson, N.A.,Ashcroft, A.E.,Kippen, A.D.,Vaughan, T.J.,Radford, S.E.,Lowe, D.C.; Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo.; Sci Rep, 6:38644-38644, 2016; PubMed: 27995962; DOI: 10.1038/srep38644

実験手法

X-RAY DIFFRACTION (3.4 Å)