5JRZ

Structure of the NS3 helicase from the French Polynesia strain of the Zika virus

Summary for 5JRZ

• Entry DOI: 10.2210/pdb5jrz/pdb
• Descriptor: Helicase, ACETATE ION, PYROPHOSPHATE 2-, ... (4 entities in total)
• Functional Keywords: zika, flavivirus, ns3, helicase, hydrolase
• Biological source: Zika virus
• Total number of polymer chains: 1
• Total formula weight: 51075.78

Authors

Jain, R.,Coloma, J.,Aggarwal, A.K. (deposition date: 2016-05-06, release date: 2016-07-06, Last modification date: 2023-09-27)

Primary citation

Jain, R.,Coloma, J.,Garcia-Sastre, A.,Aggarwal, A.K.
Structure of the NS3 helicase from Zika virus.
Nat.Struct.Mol.Biol., 23:752-754, 2016

PubMed Abstract: Zika virus has emerged as a pathogen of major health concern. Here, we present a high-resolution (1.62-Å) crystal structure of the RNA helicase from the French Polynesia strain. The structure is similar to that of the RNA helicase from Dengue virus, with variability in the conformations of loops typically involved in binding ATP and RNA. We identify druggable 'hotspots' that are well suited for in silico and/or fragment-based high-throughput drug discovery.

PubMed: 27399257
DOI: 10.1038/nsmb.3258

Experimental method

X-RAY DIFFRACTION (1.62 Å)