5JRZ

Structure of the NS3 helicase from the French Polynesia strain of the Zika virus

5JRZ の概要

• エントリーDOI: 10.2210/pdb5jrz/pdb
• 分子名称: Helicase, ACETATE ION, PYROPHOSPHATE 2-, ... (4 entities in total)
• 機能のキーワード: zika, flavivirus, ns3, helicase, hydrolase
• 由来する生物種: Zika virus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 51075.78

構造登録者

Jain, R.,Coloma, J.,Aggarwal, A.K. (登録日: 2016-05-06, 公開日: 2016-07-06, 最終更新日: 2023-09-27)

主引用文献

Jain, R.,Coloma, J.,Garcia-Sastre, A.,Aggarwal, A.K.
Structure of the NS3 helicase from Zika virus.
Nat.Struct.Mol.Biol., 23:752-754, 2016

PubMed Abstract: Zika virus has emerged as a pathogen of major health concern. Here, we present a high-resolution (1.62-Å) crystal structure of the RNA helicase from the French Polynesia strain. The structure is similar to that of the RNA helicase from Dengue virus, with variability in the conformations of loops typically involved in binding ATP and RNA. We identify druggable 'hotspots' that are well suited for in silico and/or fragment-based high-throughput drug discovery.

PubMed: 27399257
DOI: 10.1038/nsmb.3258

実験手法

X-RAY DIFFRACTION (1.62 Å)