5JQ7

Crystal structure of Ebola glycoprotein in complex with toremifene

5JQ7 の概要

• エントリーDOI: 10.2210/pdb5jq7/pdb
• 分子名称: Envelope glycoprotein 1,Envelope glycoprotein 1,Envelope glycoprotein 1, Envelope glycoprotein 2, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• 機能のキーワード: ebola virus, filoviridae, envelope glycoprotein, protein inhibitor complex, ibuprofen, toremifene, viral protein
• 由来する生物種: Ebola virus - Mayinga, Zaire, 1976; 詳細
• 細胞内の位置: GP2: Virion membrane ; Single-pass type I membrane protein . GP1: Virion membrane ; Peripheral membrane protein. GP2-delta: Secreted : Q05320
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 57593.91

構造登録者

Zhao, Y.,Ren, J.,Stuart, D.I. (登録日: 2016-05-04, 公開日: 2016-06-29, 最終更新日: 2024-01-10)

• 主引用文献: Zhao, Y.,Ren, J.,Harlos, K.,Jones, D.M.,Zeltina, A.,Bowden, T.A.,Padilla-Parra, S.,Fry, E.E.,Stuart, D.I.; Toremifene interacts with and destabilizes the Ebola virus glycoprotein.; Nature, 535:168-172, 2016; PubMed: 27362232; DOI: 10.1038/nature18615

実験手法

X-RAY DIFFRACTION (2.69 Å)