5JQ5

Crystal structure of CDK2 in complex with inhibitor ICEC0942

5JQ5 の概要

• エントリーDOI: 10.2210/pdb5jq5/pdb
• 分子名称: Cyclin-dependent kinase 2, ACETATE ION, (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol, ... (4 entities in total)
• 機能のキーワード: cdk2, kinase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34430.04

構造登録者

Hazel, P.,Freemont, P.S. (登録日: 2016-05-04, 公開日: 2017-02-08, 最終更新日: 2024-01-10)

• 主引用文献: Hazel, P.,Kroll, S.H.,Bondke, A.,Barbazanges, M.,Patel, H.,Fuchter, M.J.,Coombes, R.C.,Ali, S.,Barrett, A.G.,Freemont, P.S.; Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study.; ChemMedChem, 12:372-380, 2017; PubMed: 28125165; DOI: 10.1002/cmdc.201600535

実験手法

X-RAY DIFFRACTION (1.94 Å)