5JOP

Crystal structure of anti-glycan antibody Fab14.22 in complex with Streptococcus pneumoniae serotype 14 tetrasaccharide at 1.75 A

5JOP の概要

• エントリーDOI: 10.2210/pdb5jop/pdb
• 関連するPDBエントリー: 5JOR
• 分子名称: Fab 14.22 light chain, Fab14.22 heavy chain, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose-(1-6)-[beta-D-galactopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: s. pneumoniae serotype 14, anti-glycan b cells, synthetic conjugate vaccine, nanomolar affinity anti-glycan antibody, immune system, immune system-bacterial glycan complex
• 由来する生物種: Mus musculus; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 105887.20

構造登録者

Sarkar, A.,Irimia, A.,Teyton, L.,Wilson, I.A. (登録日: 2016-05-02, 公開日: 2017-03-22, 最終更新日: 2023-09-27)

• 主引用文献: Polonskaya, Z.,Deng, S.,Sarkar, A.,Kain, L.,Comellas-Aragones, M.,McKay, C.S.,Kaczanowska, K.,Holt, M.,McBride, R.,Palomo, V.,Self, K.M.,Taylor, S.,Irimia, A.,Mehta, S.R.,Dan, J.M.,Brigger, M.,Crotty, S.,Schoenberger, S.P.,Paulson, J.C.,Wilson, I.A.,Savage, P.B.,Finn, M.G.,Teyton, L.; T cells control the generation of nanomolar-affinity anti-glycan antibodies.; J. Clin. Invest., 127:1491-1504, 2017; PubMed: 28287405; DOI: 10.1172/JCI91192

実験手法

X-RAY DIFFRACTION (1.75 Å)