5JLZ

Crystal structure of HLA-DRB1*04:01 in complex with modified alpha-enolase peptide 26-40 with citrulline at the position 32

5JLZ の概要

• エントリーDOI: 10.2210/pdb5jlz/pdb
• 分子名称: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-4 beta chain, Alpha-enolase, ... (5 entities in total)
• 機能のキーワード: hla, autoimmune desease, rheumatoid arthritis, mhc class ii, citrulline, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P01903 P13760
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 93034.14

構造登録者

Dubnovitsky, A.,Kozhukh, G.,Sandalova, T.,Achour, A. (登録日: 2016-04-28, 公開日: 2016-12-07, 最終更新日: 2024-01-10)

• 主引用文献: Gerstner, C.,Dubnovitsky, A.,Sandin, C.,Kozhukh, G.,Uchtenhagen, H.,James, E.A.,Ronnelid, J.,Ytterberg, A.J.,Pieper, J.,Reed, E.,Tandre, C.,Rieck, M.,Zubarev, R.A.,Ronnblom, L.,Sandalova, T.,Buckner, J.H.,Achour, A.,Malmstrom, V.; Functional and Structural Characterization of a Novel HLA-DRB1*04:01-Restricted alpha-Enolase T Cell Epitope in Rheumatoid Arthritis.; Front Immunol, 7:494-494, 2016; PubMed: 27895642; DOI: 10.3389/fimmu.2016.00494

実験手法

X-RAY DIFFRACTION (1.99 Å)