5JLJ

Crystal Structure of KPT8602 in complex with CRM1-Ran-RanBP1

5JLJ の概要

• エントリーDOI: 10.2210/pdb5jlj/pdb
• 分子名称: GTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ... (9 entities in total)
• 機能のキーワード: heat repeat, exportin-1, nuclear transport, transport receptor-inhibitor complex, protein transport
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 162225.08

構造登録者

Fung, H.Y.,Chook, Y.M. (登録日: 2016-04-27, 公開日: 2016-06-29, 最終更新日: 2023-09-27)

• 主引用文献: Hing, Z.A.,Fung, H.Y.,Ranganathan, P.,Mitchell, S.,El-Gamal, D.,Woyach, J.A.,Williams, K.,Goettl, V.M.,Smith, J.,Yu, X.,Meng, X.,Sun, Q.,Cagatay, T.,Lehman, A.M.,Lucas, D.M.,Baloglu, E.,Shacham, S.,Kauffman, M.G.,Byrd, J.C.,Chook, Y.M.,Garzon, R.,Lapalombella, R.; Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies.; Leukemia, 30:2364-2372, 2016; PubMed: 27323910; DOI: 10.1038/leu.2016.136

実験手法

X-RAY DIFFRACTION (2.5 Å)