5JKP

Crystal structure of immunity protein Pa5087 from Pseudomonas aeruginosa

Summary for 5JKP

• Entry DOI: 10.2210/pdb5jkp/pdb
• Related: 5JJO
• Descriptor: Uncharacterized protein (2 entities in total)
• Functional Keywords: immunity protein, immune system
• Biological source: Pseudomonas aeruginosa PAO1
• Total number of polymer chains: 1
• Total formula weight: 30220.17

Authors

Li, Z.Q.,Gao, Z.Q.,She, Z.,Dong, Y.H. (deposition date: 2016-04-26, release date: 2016-08-31, Last modification date: 2024-10-16)

Primary citation

Yang, X.Y.,Li, Z.Q.,She, Z.,Geng, Z.,Xu, J.H.,Gao, Z.Q.,Dong, Y.H.
Structural analysis of Pseudomonas aeruginosa H3-T6SS immunity proteins
Febs Lett., 590:2787-2796, 2016

PubMed Abstract: The Pseudomonas aeruginosa PldB protein is a transkingdom effector secreted by the Type VI Secretion System (T6SS). PA5088, PA5087, and PA5086 are three immunity proteins that can suppress the virulence of PldB. We report the crystal structures of PA5088 and PA5087 at 2.0 and 2.1 Å resolution, respectively. PA5088 and PA5087 both consist of several Sel1-like Repeats (SLRs) and form super-ring folds. Our structural analysis of these proteins revealed key differences among PA5088, PA5087, and their homologs. Our docking experiments have shed light on the putative interaction mechanism of their function as phospholipase D inhibitors.

PubMed: 27397502
DOI: 10.1002/1873-3468.12291

Experimental method

X-RAY DIFFRACTION (2.106 Å)