5JK3

Crystal structure of TL11-128 bound to TAK1-TAB1

5JK3 の概要

• エントリーDOI: 10.2210/pdb5jk3/pdb
• 分子名称: Mitogen-activated protein kinase kinase kinase 7,TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, ~{N}-[2-[5-chloranyl-2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide (2 entities in total)
• 機能のキーワード: mitogen activated protein kinase kinase kinase 7, tgf-beta activated kinase 1 and map3k7-binding protein 1 chimera, serine/threonine kinase which act as essential component of the map kinase signal transduction pathway, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35834.66

構造登録者

Gurbani, D.,Westover, K.D. (登録日: 2016-04-25, 公開日: 2017-02-15, 最終更新日: 2023-09-27)

• 主引用文献: Tan, L.,Gurbani, D.,Weisberg, E.L.,Hunter, J.C.,Li, L.,Jones, D.S.,Ficarro, S.B.,Mowafy, S.,Tam, C.P.,Rao, S.,Du, G.,Griffin, J.D.,Sorger, P.K.,Marto, J.A.,Westover, K.D.,Gray, N.S.; Structure-guided development of covalent TAK1 inhibitors.; Bioorg. Med. Chem., 25:838-846, 2017; PubMed: 28011204; DOI: 10.1016/j.bmc.2016.11.035

実験手法

X-RAY DIFFRACTION (2.371 Å)