5JJO

The crystal structure of immunity protein PA5088 from Pseudomonas aeruginosa

5JJO の概要

• エントリーDOI: 10.2210/pdb5jjo/pdb
• 関連するPDBエントリー: 5JKP
• 分子名称: Uncharacterized protein, GOLD ION (3 entities in total)
• 機能のキーワード: immunity protein, immune system
• 由来する生物種: Pseudomonas aeruginosa PAO1
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31778.29

構造登録者

Li, Z.Q.,Gao, Z.Q.,She, Z.,Dong, Y.H. (登録日: 2016-04-24, 公開日: 2016-08-31, 最終更新日: 2024-10-23)

主引用文献

Yang, X.Y.,Li, Z.Q.,She, Z.,Geng, Z.,Xu, J.H.,Gao, Z.Q.,Dong, Y.H.
Structural analysis of Pseudomonas aeruginosa H3-T6SS immunity proteins
Febs Lett., 590:2787-2796, 2016

PubMed Abstract: The Pseudomonas aeruginosa PldB protein is a transkingdom effector secreted by the Type VI Secretion System (T6SS). PA5088, PA5087, and PA5086 are three immunity proteins that can suppress the virulence of PldB. We report the crystal structures of PA5088 and PA5087 at 2.0 and 2.1 Å resolution, respectively. PA5088 and PA5087 both consist of several Sel1-like Repeats (SLRs) and form super-ring folds. Our structural analysis of these proteins revealed key differences among PA5088, PA5087, and their homologs. Our docking experiments have shed light on the putative interaction mechanism of their function as phospholipase D inhibitors.

PubMed: 27397502
DOI: 10.1002/1873-3468.12291

実験手法

X-RAY DIFFRACTION (2.002 Å)