5JG0
Staphylococcus aureus Dihydrofolate Reductase complexed with beta-NADPH and UCP1191
Summary for 5JG0
Entry DOI | 10.2210/pdb5jg0/pdb |
Descriptor | Dihydrofolate reductase, 4-{6-[(2S)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-2H-1,3-benzodioxol-4-yl}benzoic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
Functional Keywords | oxidoreductase, dihydrofolate reductase, nadph, zwitterion, antibiotics |
Biological source | Staphylococcus aureus |
Total number of polymer chains | 1 |
Total formula weight | 19189.42 |
Authors | Anderson, A.C.,Reeve, S.M. (deposition date: 2016-04-19, release date: 2017-04-19, Last modification date: 2024-03-06) |
Primary citation | Reeve, S.M.,Scocchera, E.W.,G-Dayanadan, N.,Keshipeddy, S.,Krucinska, J.,Hajian, B.,Ferreira, J.,Nailor, M.,Aeschlimann, J.,Wright, D.L.,Anderson, A.C. MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates. Cell Chem Biol, 23:1458-1467, 2016 Cited by PubMed: 27939900DOI: 10.1016/j.chembiol.2016.11.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.879 Å) |
Structure validation
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