5JG0

Staphylococcus aureus Dihydrofolate Reductase complexed with beta-NADPH and UCP1191

5JG0 の概要

• エントリーDOI: 10.2210/pdb5jg0/pdb
• 分子名称: Dihydrofolate reductase, 4-{6-[(2S)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-2H-1,3-benzodioxol-4-yl}benzoic acid, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, dihydrofolate reductase, nadph, zwitterion, antibiotics
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19189.42

構造登録者

Anderson, A.C.,Reeve, S.M. (登録日: 2016-04-19, 公開日: 2017-04-19, 最終更新日: 2024-03-06)

• 主引用文献: Reeve, S.M.,Scocchera, E.W.,G-Dayanadan, N.,Keshipeddy, S.,Krucinska, J.,Hajian, B.,Ferreira, J.,Nailor, M.,Aeschlimann, J.,Wright, D.L.,Anderson, A.C.; MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates.; Cell Chem Biol, 23:1458-1467, 2016; PubMed: 27939900; DOI: 10.1016/j.chembiol.2016.11.007

実験手法

X-RAY DIFFRACTION (1.879 Å)