5JD7
PKG I's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with PET-cGMP
Summary for 5JD7
Entry DOI | 10.2210/pdb5jd7/pdb |
Descriptor | cGMP-dependent protein kinase 1, 3-[(2S,4aR,6R,7R,7aS)-2,7-dihydroxy-2-oxotetrahydro-2H,4H-2lambda~5~-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-6-phenyl-3,4-dihydro-9H-imidazo[1,2-a]purin-9-one (3 entities in total) |
Functional Keywords | binding sites, cyclic amp, cyclic gmp, cyclic gmp-dependent protein kinase type ii, mutagenesis, site-directed, protein binding, analogs |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm : Q13976 |
Total number of polymer chains | 1 |
Total formula weight | 15432.06 |
Authors | Campbell, J.C.,Sankaran, B.,Kim, C.W. (deposition date: 2016-04-15, release date: 2017-08-09, Last modification date: 2023-09-27) |
Primary citation | Campbell, J.C.,Henning, P.,Franz, E.,Sankaran, B.,Herberg, F.W.,Kim, C. Structural Basis of Analog Specificity in PKG I and II. ACS Chem. Biol., 12:2388-2398, 2017 Cited by PubMed: 28793191DOI: 10.1021/acschembio.7b00369 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.749 Å) |
Structure validation
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