5JAW
Structure of a beta galactosidase with inhibitor
Summary for 5JAW
| Entry DOI | 10.2210/pdb5jaw/pdb |
| Descriptor | Beta-galactosidase, putative, bgl35A, (1S,2S,3S,4S,5R,6R)-5-amino-6-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol, SODIUM ION, ... (5 entities in total) |
| Functional Keywords | beta galactosidase, inhibitor, aziridine, hydrolase |
| Biological source | Cellvibrio japonicus (strain Ueda107) |
| Total number of polymer chains | 8 |
| Total formula weight | 499195.56 |
| Authors | Offen, W.,Davies, G. (deposition date: 2016-04-12, release date: 2017-05-10, Last modification date: 2024-10-23) |
| Primary citation | Schroder, S.P.,van de Sande, J.W.,Kallemeijn, W.W.,Kuo, C.L.,Artola, M.,van Rooden, E.J.,Jiang, J.,Beenakker, T.J.M.,Florea, B.I.,Offen, W.A.,Davies, G.J.,Minnaard, A.J.,Aerts, J.M.F.G.,Codee, J.D.C.,van der Marel, G.A.,Overkleeft, H.S. Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines. Chem. Commun. (Camb.), 53:12528-12531, 2017 Cited by PubMed Abstract: Activity-based protein profiling has emerged as a powerful tool for visualizing glycosidases in complex biological samples. Several configurational cyclophellitol isomers have been shown to display high selectivity as probes for glycosidases processing substrates featuring the same configuration. Here, a set of deoxygenated cyclophellitols are presented which enable inter-class profiling of β-glucosidases and β-galactosidases. PubMed: 29116266DOI: 10.1039/c7cc07730k PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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